Histamine Receptor Agonist

Histamine Receptor Agonists (35):

Cat. No.	Product Name	Effect	Purity

HY-B0722

Histamine dihydrochloride	Agonist	99.68%
Histamine dihydrochloride is the agonist for histamine receptor and a vasodilator. Histamine dihydrochloride is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine dihydrochloride affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma.

HY-A0129

Histamine phosphate	Agonist	99.34%
Histamine phosphate is the agonist for histamine receptor and a vasodilator. Histamine phosphate is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine phosphate affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine phosphate can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma.

HY-101063

Amthamine dihydrobromide	Agonist	99.64%
Amthamine is a histamine receptor (H1R-H4R) agonist. Amthamine can produce liver congestion and necrosis of liver cells. Amthamine can be used to study the induction effect of H1R-H4 agonist on hepatotoxicity .

HY-107565

2-Pyridylethylamine hydrochloride	Agonist	99.86%
2-Pyridylethylamine is a histamine-1 (H1R) receptor agonist. 2-Pyridylethylamine can reduce the joint injury induced by formalin in rats. 2-Pyridylethylamine can be used to study the spinal cord release of neuropeptide (NPY) .

HY-12752A

Alimemazine hemitartrate	Agonist	98.44%
Alimemazine hemitartrate (Trimeprazine hemitartrate) is an antagonist of the histamine (HA) receptor that can be taken orally and also acts as a partial agonist at other GPCR receptors. Alimemazine hemitartrate has effects that include anti-serotonin, antispasmodic, antihistamine, sedation, hypnotic, antiviral, and anti-nausea properties. Alimemazine hemitartrate promotes the growth of pancreatic β-cells in mice and improves diabetes in mice.

HY-B1204R

Histamine (Standard)	Agonist
Histamine (Standard) is the analytical standard of Histamine (HY-B1204). This product is intended for research and analytical applications. Histamine is the agonist for histamine receptor and a vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma.

HY-B0722R

Histamine dihydrochloride (Standard)	Agonist
Histamine dihydrochloride (Standard) is the analytical standard of Histamine dihydrochloride (HY-B0722). This product is intended for research and analytical applications. Histamine dihydrochloride is the agonist for histamine receptor and a vasodilator. Histamine dihydrochloride is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine dihydrochloride affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma.

HY-W580721A

4-Methylhistamine hydrochloride	Agonist
4-Methylhistamine (hydrochloride) is a potent, high affinity H4 receptor agonist K_i of 7 nM. 4-Methylhistamine (hydrochloride) displays more than 100-fold selectivity over other human histamine receptor subtypes.

HY-122608

Samelisant free base	Agonist
Samelisant (SUVN-G3031) free base is a potent and selective histamine H3 receptor (H3R) inverse agonist with good brain penetration and oral bioavailability. Samelisant free base has a similar binding affinity towards human (hH3R; K_i=8.7 nM) and rat (rH3R;K_i=9.8 nM) H3R indicating no inter-species differences. Samelisant free base can be used for the research of sleep-related disorders.

HY-107554

Methimepip dihydrobromide	Agonist
Methimepip dihydrobromide is a potent and selective histamine H3 receptor agonist with an EC₅₀ of 0.316nM.

HY-108058A

Immethridine dihydrobromide	Agonist
Immethridine dihydrobromide is a selective histamine H3 receptor (H3R) agonist. Immethridine dihydrobromide displays 300-fold selectivity over the H4 receptor and does not bind to H1 or H2 receptors. Immethridine dihydrobromide can be used for experimental autoimmune encephalomyelitis (EAE) research.

HY-B0377G

Famotidine (GMP)	Agonist
Famotidine GMP (MK-208 GMP) is Famotidine (HY-B0377) produced in GMP guideline. Famotidine GMP is a competitive histamine H2-receptor antagonist, inhibits gastric secretion, activates the gastric mucosal defensive mechanisms. Famotidine GMP ameliorates peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD) in rats model.

HY-108977

VUF 8430	Agonist
VUF 8430 is a potent and selective histamine H4 receptor agonist with a K_i of 31.6 nM and an EC₅₀ of 50 nM.

HY-W580721

4-Methylhistamine	Agonist
4-Methylhistamine is a potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine has the potential for the research of immune-related diseases such as cancer and autoimmune disorders.

HY-A0129R

Histamine phosphate (Standard)	Agonist
Histamine phosphate (Standard) is the analytical standard of Histamine phosphate (HY-A0129). This product is intended for research and analytical applications. Histamine phosphate is the agonist for histamine receptor and a vasodilator. Histamine phosphate is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine phosphate affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine phosphate can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma.

HY-12752BS

Alimemazine-d₆ hydrochloride	Agonist
Alimemazine-d6 hydrochloride (Trimeprazine-d6 hydrochloride) is the deuterium labeled Alimemazine (HY-12752). Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties.

HY-120541A

ST-1006 Maleate	Agonist
ST-1006 maleate is a potent histamine H4 receptor agonist with a pK_i value of 7.94. ST-1006 maleate has anti-inflammatory effect.

HY-113802

VUF 8328	Agonist
VUF 8328 is a potent histamine H(3) receptor agonist. VUF 8328 inhibits the electrically-evoked [³H]-no-radrenaline release from rat cortical slices. VUF 8328 is promising for research of central nervous system disorders.

HY-101005

N-Methylhistamine dihydrochloride	Agonist
N-Methylhistamine (Nα-Methylhistamine) dihydrochloride is a potent agonist of the histamine H3 receptor, exhibiting significant implications in the diagnosis and management of mastocytosis. N-Methylhistamine (dihydrochloride) also serves as a biomarker for assessing mast cell accumulation in clinical evaluations.

HY-B1204S2

Histamine-¹³C₅, ¹⁵N₃	Agonist
Histamine-¹³C₅, ¹⁵N₃ (Ergamine-¹³C₅, ¹⁵N₃) is the ¹³C and ¹⁵N labeled isotope of Histamine (HY-B1204). Histamine is the agonist for histamine receptor and a vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma.

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